Synaptic plasticity, cortical plasticity, sensory, memory, emotion, spinal cord, hippocampus, cortex, pain, pleasure, chronic pain, fear, aging, schizophrenia, Alzheimer’s disease

min.zhuo@utoronto.ca

(416) 978-4018

(416) 978-4940

Blood Conservation, Neuroanesthesia
Critical Illness and Injury
His clinical focus is to develop multimodal and inter-professional approaches to optimize patient outcomes through patient blood management strategies.
Next to lab-based research, we also perform clinical research focused on CFTR-related disorder, gastrointestinal disease in CF and pancreas diseases in children.
Smiles!
Tickling

(1) Developmental changes in the physiology and pharmacology of the prefrontal cortex
Scholarship of Teaching and Learning (SoTL)
1) Understanding cell type specific gene transcription. 2) Mechanisms underlying the production and function and the incretin hormone GLP-1. 3) Role of Wnt signaling pathway in metabolic homeostasis.
1) Understanding cell type specific gene transcription. 2) Mechanisms underlying the production and function and the incretin hormone GLP-1. 3) Role of Wnt signaling pathway in metabolic homeostasis.
1. Gene-environment interactions during development and disease susceptibility. 2. Fetal protection against drugs and environmental toxins
1. Genome wide gene trapping and mutagenesis in zebrafish 2. Large scale high throughput chemical genetic screening for in vivo drug discovery using zebrafish embryos 3. Functional genomics and disease modeling
a brain region critical for attention and emotional regulation. (2) We are studying the effects of environmental and genetic manipulations that are relevant to attention and anxiety disorders.
Acute Intestinal Injury
Acute lung injury
Acute lung injury, lung transplantation, lung injury, repair and regeneration, drug discovery, signal transduction, cell biology,
acute respiratory distress syndrome
Acute respiratory distress syndrome: definitions; ventilatory management; trial design
addiction and the adolescent brain; Human epigenome in health and disease; Induction of brown fat as a protection against diet-induced obesity
Adipocytes
adiposity and cardiovascular diseases with special emphasis on high density lipoprotein (HDL) metabolism.
Administration of animal care programs
Affiliated platform: Neuroscience.
Affiliated platform: Neuroscience; Cardiovascular & Respiratory.
aging
All my research efforts are focused on aspects of placental development and pathology. My clinical research interests focus on screening and prevention of placental complications of pregnancy.
Alzheimers' and Parkinson's disease.
Alzheimer’s disease
amino acids and food intake; dietary control of peptide hormone and neurotransmitter metabolism. Food composition
and 2. Central and peripheral signals controlling neuronal cell types expressing neuropeptides linked to the regulation of energy homeostasis (CIHR).
and assisted reproductive technology including embryology.
and defects in diabetes.
and fetal alcohol spectrum disorder
and identifying potential therapeutic targets for stroke.
and physiological mechanisms of insulin resistant states (type 2 diabetes
and pulmonary vascular diseases. Specific interests include mechanisms of neuronal sensing and modulation of immune responses
and receptor tyrosine kinases.
and the cellular and molecular mechanisms of acute lung injury.
and the changes in synaptic biochemistry and morphology that occur when NMDA receptors are dysfunctional.
and the implication of these effects for the pathogenesis of diabetes. Secondary themes of research are the studies of the effects of nutrient and insulin excess on: i) atherosclerosis and restenosis; ii) mammary and colorectal cancer
and their roles in diabetes
and together
and Tourette Syndrome. Functional studies of genomic regions identified in genetic risk for psychiatric disorders and immune mediated disorders.
androgen receptor action
Andrology
Anemia, Hypoxia, Oxygen Delivery
Anesthesiology; Critical care; Cardiac surgery; Cardiovascular metabolism and physiology; Transfusion medicine.
Angiogenesis
Animal Models
Animal models of brain diseases
Animal models of neurodegenerative disease. Behavioural testing to phenotype genetically engineered mouse models.
appetite and health; proteins
as well as human cortical trissue removed at surgery for epilepsy.
Assisted Reproductive Technology
Asthma
astrocytes
Atherosclerosis
Attention Deficit/Hyperactivity Disorder
Behaviour
behaviour and electrophysiology.
bioinformatics
biological constraints.
blood flow regulation
body surface and intracardiac recordings
Brain
Brain Injury
Brain tumors
Business economics; business of science and development; innovation in the governance of technology to improve global health; management and business mechanisms
business of science and development; innovation in the governance of technology to improve global health; management and business mechanisms
calcium binding protein
Cardiac
Cardiac muscle
Cardio-pulmonary physiology; vascular reactivity; cerebral vascular disease; coronary vascular disease; hypoxia; hypercapnia; carbon monoxide kinetics; pharmacokinetics of anesthetic vapours.
Cardiology
cardiomyopathy
cardiovascular physiology
Career Training for Graduate Students
Carotid artery disease
Cat Platform
-Cat food
-Cats
Cell biology
Cell Calcium
Cell Cycle & Proliferation
cell signaling.
cell theory
Cellular and molecular mechanisms of pulmonary vascular remodelling and right heart failure in chronic pulmonary hypertension
Cellular and molecular mechanisms which control formation of the normal and malformed mammalian kidney and cerebellum. Growth factor signaling during tissue morphogenesis with particular focus on Hedgehog signaling.
Cellular and molecular mechanisms which control formation of the normal and malformed mammalian kidney. Growth factor signaling during tissue morphogenesis with particular focus on Hedgehog signaling.
Cellular and molecular mechanisms which control formation of the normal and malformed mammalian kidney; growth factor signaling; murine and organoid models of human kidney disease.
Cellular Electrophysiology / Patch-Clamp Electrophysiology / Fluorescence Imaging / Cellular Neuroimmunology / Cellular Neurobiology
cellular electrophysiology and mouse models.
central nervous system
Central Nervous System (CNS)
Cerebral arterial bypass surgery
Cerebral tissue; oxygen delivery
Cerebrovascular surgery
channelopathy
childhood-onset depression
chronic heart failure
chronic pain
Circuits that support cognition in the healthy and injured brain; Neuroimaging based on biomarkers in paediatric traumatic brain injury (TBI); Vulnerable periods of neurodevelopment
clinical studies of anaesthetics.
Cochlear implantation.
commitment and development; Trophoblast; Placenta; Preeclampsia
Computational and translation neuroscience
Computational neuroscience
Computational neuroscience (neural coding
Computational neuroscience, cortical circuits, models, neuronal cell-types, connectivity, depression, schizophrenia
connectomics, digital cell reconstruction
Control of presynaptic transmitter release. Mechanisms of exocytosis in neuronal and immune cells
cortex
cortical circuits
cortical plasticity
Critical Care
cytokine
defensin biology
defining the roles of G proteins and their regulators in the cardiovascular system.
Dendritic spine and synaptogenesis
Development
Development of novel therapeutics (protein peptide/small molecules) for the treatment of neuro-psychiatric diseases such as drug addiction
development.
Diabetes
Diabetes/Lipotoxicity/Glucotoxicity/ Insulin resistance/ Insulin Secretion/ Oxidative stress/ Clamps/Atherosclerosis/ Restenosis/ Cancer
Diabetic Nephropathy
dietary status and chronic disease.
Doppler
Dr. Hill has developed numerous large-scale models of cortical and corticothalamic systems during wakefulness
Dr. Kadis studies brain-behaviour relationships and neuroplasticity in healthy development and disease. Specifically
Dr. Kadis studies brain-behaviour relationships and neuroplasticity in healthy development and disease. Specifically
drug discovery
dynamical systems theory
dystonia and essential tremor Research interests include mechanisms of deep brain stimulation action
dystonia and essential tremor.
early development origins
Eating behaviour
Effect of left ventricular afterload in the setting of: 1. Patent Ductus Arteriosus 2. Pulmonary Hypertension 3. Acute Hypoxemia
Effects of anaesthetics on ligand-gated ion channels
electrophysiology
Electrophysiology of epithelial cells: the role of ion conductance in epithelium secretory responses and volume regulation.
emotion
Endocrine and Diabetes Platform
Endocrinology
Endocrinology of pregnancy; molecular regulation of myometrial
epidemiology
epigenetics
epilepsy, genomics, neurodegeneration
faculty development
fear
Focus on delineating host immune responses to infection and its relation to disease pathogenesis. Understanding the mechanisms responsible for Helicobacter pylori-mediated gastrointestinal disease. Autophagy in gastrointestinal disease.
focusing on their role in the pathophysiology of schizophrenia and the treatment of depression. Current projects in the lab examine the plasticity of neural circuits that are relevant to schizophrenia
Food intake regulation; carbohydrates
Friendship
G x E interactions
gene based therapy
Gene-environment interactions during development and disease susceptibility
Genetic manipulations in mice
genetics
Genetics of complex traits
germfree technology and operations
glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) and their roles in regulating growth and function of the beta-cell and the in.
glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) and their roles in regulating growth and function of the beta-cell and the intestinal tract
glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) and their roles in regulating growth and function of the beta-cell and the intestinal tract..
Glucose Transport
Glutamate receptors
Graduate Professional Development
graduate students
growth and connectivity; Role of p53 family in the nervous system; Molecular regulation of neurogenesis
Growth Factors; Oxidative stress; Vascular Remodeling; Vasoconstriction; Cardiac Failure
Health research funding policies
Health research funding policies; educational and research initiatives that are focused on translational sciences
Heart
Heart/ Development/ Gender/ Sex Hormones/ Metabolism/ Oxygen Stress/ Hypertrophy/ Hypertension/ Mercury/ Heavy Metals/ Marine Mammals/ Contaminants
Hemodynamics
Heparin
hepatic VLDL-TG secretion and food intake to maintain glucose
High-frequency oscillatory ventilation
higher-order learning
hippocampus
his lab uses advanced neuroimaging to characterize network architecture and gross physiology (structure
hormones
Host–pathogen interactions in respiratory viral infections
Human Models
human modules
Hypertension
hypoglycemia
imaging
imaging and molecular biological techniques from in vitro and in vivo brain tissue
immune dysregulation in neuropathic pain and pulmonary vascular disease.
immunity
immunohistochemistry
implementing change
in particular free fatty acids
in particular the role of prosclerotic cytokines and extracellular matrix upon cardiac diastolic function in disease states such as hypertension and diabetes.
including both innate immune activation and B cell dysfunction and autoimmunity.
including pharmacology
including strain and strain rate. Right ventricular response and right and left ventricular interactions in experimental models of right ventricular pressure and volume loading.
including: Necrotizing enterocolitis (NEC)
infant pulmonary function
Infection
infertility including male infertility
information theory)
Insulin Receptor
Insulin Resistance
insulin secretion
integrative
intergenerational effects
intervention studies
Intestinal organoids and Randomized Controlled Trials (RCT)
Intracranial aneurysms and vascular malformations
Investigating how epigenetic factors influence neuronal function.
Investigation of the effects of excess circulating energy substrates
ion channels
ion homeostasis and contractile function of hearts with acquired and inherited cardiovascular disease
Learning and memory in mice
learning, neuron-glial networks
lipid and energy homeostasis
Lung and vascular physiology.
lung injury
lung transplantation
major depression
Mathematical modeling; Computational Neuroscience; Inhibitory cell models.
Mechanical Ventilation
Mechanical ventilation: epidemiology; weaning and liberation; extubation and tracheostomy
Mechanisms and Functions of adult neurogenesis in the mammalian brain.
Mechanisms of dilated cardiomyopathy; Ca2+ regulation in skeletal and cardiac muscle; formation of specialized protein domains in muscle; cardiovascular proteomics.
Mechanisms of heterotrimeric G protein signaling
Mechanisms of lung barrier dysfunction
Mechanisms of sleep
Membrane and synaptic properties of mammalian CNS neurons/glia; Physiological
memory
menopausal hormonal replacement therapy
Mesangial cells
metabolic syndrome)
microbiome
microglia, calcium signaling, Alzheimer’s disease
MicroRNA-based gene therapeutics
models
molecular
molecular and cellular mechanisms that regulate the assembly and operation of motor circuit development and locomotion.
Molecular basis of ion channel function and identification of drug binding sites. Electrical behaviour
Molecular Biology
Molecular physiology of islet biology – metabolism
mood
morphology and developmental plasticity of the normal and pathological auditory system. Hearing disorders
Mouse genetic models of cognitive function and dysfunction.
mouse models
multiple sclerosis and stroke.
My laboratory is focused on the molecular mechanisms which regulate exocytosis
My laboratory is interested in characterizing chromatin proteins to decipher their functions in chromatin dynamics and gene regulation and implications in human diseases.
My research aims are two-fold; 1) to examine the neural substrates of memory and 2) to apply these basic findings to study potential treatments for people with learning and memory disorders
My research group within the Toronto General Research Institute focuses on translational research to apply new insights to clinical applications for cardiac repair and regeneration.
My research lab is primarily interested in the area of genetics of lipid disorders
My research program is divided into two main themes: 1. Control of GnRH neuronal function by steroid hormones and afferent neuronal input (CIHR)
My research uses electroencephalography (EEG) to study cognition and sensory processing associated with hearing loss and aging. Our projects mostly focus on speech perception in human adults who have had their hearing restored using cochlear implants.
myelin-axon interactions and functional properties of myelinated axons in the CNS.
myometrial contractility in response to various anesthetics, uterotonic and tocolytic drugs
nano-drug formulation
Neural and non-neural mechanisms of oral-facial pain; mastication
neural dynamics) supporting eloquent function in childhood.
neural dynamics) that support eloquent function in childhood.
Neural stem cells; Neurotrophin regulation of neuronal survival
Neurobiology of attention and emotional regulation
Neurobiology of sleep and sleep disorders
neurodevelopmental and neurogenerative disorders.
Neuroimmunology of inflammatory responses, programmed cell death pathways, and pain
Neuron-glial interactions
neuronal cell-types
neuronal excitability
Neurooncology
Novel ventilatory support: High-frequency oscillatory ventilation; Extra-corporeal life support
obesity
Obesity and cardio-metabolic disease in adolescence; Eating behavior
on insulin action
onset of term/pre-term labour
Optogenetics
Organization of the living myelin sheath
Organization of the living myelin sheath and myelin-axon interactions.
Organization of the living myelin sheath, myelin-axon interactions and functional properties of myelinated axons in the CNS; functional assessment of engineered stem cells for spinal cord injury research
Our lab group is currently focused on the epigenetics of benign (or not) urological disease.
Our lab studies NMDA receptors
Our main focus has been to elucidate nutrient and hormone sensing mechanisms in the gut and the brain that regulate hepatic glucose production
Our research focuses on how membrane traffic is controlled by SNARE proteins and by the septin proteins of the cytoskeleton. We study this in the context of neurotransmitter release and in cell division.
Our research interest is in studying the role of ion channels in neuroprotection against cerebral ischemia and stroke
Ovarian biology; Early embryo development.
Ovarian cancer
Oxidative Stress
pain
pain processing.
Parkinson’s disease
Pathology
patient-specific induced pluripotent stem cells for regeneration of urethral sphincter in women with Stress Urinary Incontinence.
Pee-clinical animal models
Peripheral vascular physiology; vasospasm; thrombosis; angiogenesis; wound healing; ischemia/reperfusion injury in vivo and in vitro.
phagocytosis
pharmacological and pathological studies of seizure disorders
physiological studies in humans.
Physiological, pharmacological and genetic mechanisms to understand postpartum uterine atony and hemorrhage
Physiology
Pickleball
Placenta
Placental Ultrasound
placental/fetal develoment
Platelet Physiology and Thrombosis; Platelet Immunology and Maternal Immune Response to Fetal Antigens
pleasure
Podocytes
Pre-eclampsia
pregnancy cohorts
Presynaptic and postsynaptic mechanisms underlying excitatory synaptic transmission in the mammalian central nervous system.
Preterm Labour
prevention of preterm delivery.
Protection with C02
Protein Tyrosine Phosphatase
puberty
Puberty, Diabetes, Hormones, Genetics, Brain Structure
Purine and excitatory amino acid neurotransmitters in the spinal cord; synaptic transmission and plasticity in pain pathways.
rare disease
Regulation of cell membrane ion channels and intracellular ion levels and dynamics; Raw Data Research; Global Health Quality
Regulation of glucose transport in skeletal muscle by insulin
Relationship between cardiovascular physiology and brain development in the fetus and newborn
repolarization
Reproductive tissue cancers
research associates and technicians
Research focuses on pulmonary vascular inflammation and vasoconstriction. Specific interests include mechanisms of immunological dysregulation in pulmonary arterial hypertension
Research in Dr. Mount's lab focuses on discerning signaling defects in knockout and transgenic mouse models of ataxia telangiectasia
Research in my lab is centered around the cellular and molecular mechanisms of neuronal damage during stroke and other injuries such as epilepsy and trauma.
Research interests are in the assessment of ventricular function in children with acquired and congenital heart disease and in the use of new echocardiography technologies
Research interests include mechanisms of Pelvic Organ Prolapse development
Research is directed towards cystic fibrosis, assessing CFTR function and interaction with other epithelial channels in human airway and intestinal cells.
Research is directed towards Neonatal Intestinal Disorders Requiring Surgery
Research is directed towards neurophysiology of Parkinson’s disease
Research is directed towards the neuroimmunology of inflammatory responses
Research is directed towards understanding the genetic causes and physiology of cardiac heart rhythm disorders through use of human genetic studies
respiratory medicine
Respiratory muscle action and function during mechanical ventilation; mechanisms of lung and diaphragm injury in respiratory failure; management of acute respiratory failure, mechanical ventilation, and extracorporeal life support
rhythm generation and regulation
role of neuronal oscillations in Parkinson’s disease
schizophrenia
Scholarship of teaching and learning
second messenger systems
secretion and biological activities of intestinal peptide hormones
secretion and kinetics
sedation and anesthesia. Mechanisms of sleep and drug-induced respiratory depression. Interdisciplinary and collaborative research and educational programs encompassing sleep
sedation and anesthetic sciences
sensory
sepsis
Sex hormone regulation of inflammation and susceptibility to Pseudomonas aeruginosa in cystic fibrosis (CF) airways. The impact on long-term respiratory risk of developmental deficiency of Lgl1.
Signal Processing and Adaptive Filtering; Bio-sensors and Wearable Neurotechnology
signal transduction
signaling pathways in ovarian cancer progression
Signaling pathways that calcium-independently regulate resistance artery tone
sleep and anesthetic conditions. His work has contributed to our understanding of the mechanisms generating up and down states during the slow oscillation of sleep as well as plasticity and sensory responses during sleep.
Smooth Muscle Cell
Specific interests include mechanisms of neuronal sensing and modulation of immune responses, immune dysregulation in neuropathic pain and preclinical models of disease.
spinal cord
Spinal tumors
Spinal vascular malformations
Statistical Signal Processing and Bayesian Inference; Neural Networks
Stem Cells
steroid hormone signaling modulation by co-regulatory proteins
stress
Stress response
student motivation
such as Alzheimer's disease and inherited forms of mental retardation.
sudden death
swalling and related motor functions
swalling and related motor functions.
swallowing and related sensorimotor functions.
sweeteners
Synapse formation
synaptic physiology
Synaptic plasticity
synaptic plasticity, memory
synaptic transmission
Synaptic transmission and plasticity
System Neuroscience; Information Theory
Systems biology; Bioinformatics; Gene regulation; Lineage specification
The aim of my research is to understand the fundamental biological and physiological mechanisms that direct lung development and the impact of preterm birth on this process.
The focus of Dr.O’Brien’s lab is to identify the molecular pathways responsible for driving tumour growth in colorectal cancer. The ultimate goal being to utilize this knowledge to devise improved therapeutic strategies for colorectal cancer.
The focus of my laboratory is the study of hematopoietic and mesenchymal stem cells.
The Lam lab consists of post-doctoral fellows
The Lewis lab performs whole body
The link between insulin resistant diabetes and dysregulation of lipoprotein metabolism
The mechanism of information transfer between neurons with particular focus on the function of the presynaptic nerve terminal. The direct examination of presynaptic ion channel activity and its relation to transmitter release.
The Nostro laboratory is interested in elucidating the molecular regulators controlling pancreatic development and beta cell maturation.
the pathogenesis of pulmonary hypertension syndrome of the newborn and mechanical ventilation induced lung injury.
The physiology of the pulmonary circulation during the transition from fetal to neonatal life
the role of ovarian hormones in the prevention of pelvic floor deterioration; use of urine-derived
The underlying cellular
Theoretical and Computational Neuroscience
they aim to unveil novel theraptic molecular targets in the gut and the brain that lower blood glucose and lipid levels as well as body weight in diabetes and obesity.
Thiredoxin-interacting protein
Thiredoxin-interacting protein.
Three areas of research
thyroid function
Tissue-specific synthesis
toll-like receptors.
Transcriptional Regulation
Transgenic Mice
Translational animal models of critical illness
translational research
Trophoblast
tumorignesis
Tyrosine Kinase
umbilical and uterine vascular contractility in response to vasopressors; plasma oxytocin levels.
Undergraduate education
using electrophysical recordings
using two models- the neuroendocrine insulin-secreting pancreatic islet beta cell and the epithelial pancreatic acinar cell which secrete digestive enzymes.
Vascular Biology
ventilation induced lung injury
voltage-dependent calcium channels
We aim to develop novel therapeutic strategies to treat and even cure Type 1 diabetes (T1D) and Type 2 diabetes (T2D)
We are focusing on the ischemia-reperfusion induced lung injury in lung transplantation
we need to know more about the principles of control in general; hence we see our field as a branch of mathematical control theory
We study how the brain learns to control motor behavior. To understand the mechanisms
We use a multi-pronged approach.
with a focus on childhood-onset psychiatric disorders and cognitive function including reading disabilities (developmental dyslexia)
with a focus on lipid and lipoprotein metabolism.
with a particular focus on the proglucagon-derived peptides
with extra
Work in the lab ranges from molecular genotyping of human and rodent DNA samples to phenotyping pain in humans and rodent models of neuropathy
• Circuits that support cognition in the healthy and injured brain

Faculty Directory

Haibo Zhang PhD

Research Interests

Mei Zhen PhD

Research Interests

Min Zhuo PhD

Research Interests

Pagination