JCV3064H - Advanced Topics in Cardiovascular Sciences: Microvascular Medicine

Course Coordinator:

S. Bolz


This course is one of a set of five advanced seminar half-credit courses dealing with current research areas in the cardiovascular system. Specifically, JCV3064H will provide a translational perspective on Microvascular medicine and progress from new molecular concepts of microvascular function to evaluating their clinical applicability and therapeutic value.

Areas that may be covered include:

  • Microvascular endothelial function and dysfunction

  • Molecular signaling in the Microvascular smooth muscle – specific focus on myogenic responsiveness

  • Microcirculation in the lung 

  • Molecular mechanisms underlying Microvascular dysfunction following subarachnoid hemorrhage

  • Aging microcirculation

  • Diabetes-associated Microvascular dysfunction

  • Microvascular function during general anaesthesia

  • Circadian rhythmicity in microvascular function

  • Phenomenon of neovascularization

  • New experimental platforms to assess microvascular function

  • Overview of recent clinical trials on therapeutic strategies targeting the function and/or structure of the microcirculation




Graduate students interested in heart research. Preference will be given to students enrolled in the Cardiovascular Sciences Collaborative Program.


10%    essay outline
30%    student presentation – oral presentation on final term paper
40%    final essay – subject dealing with a lecture topic
15%    student seminar contributions and participation
  5%    attendance

Last updated: 21-Apr-2015