Mark Friedberg

Cardiovascular Platform


Labatt Family Heart Centre, Division of Cardiology, , Hospital for Sick Children, 555 University Ave, Toronto, Ontario Canada M5G 1X8
Research Interests
Research interests are in the assessment of ventricular function in children with acquired and congenital heart disease and in the use of new echocardiography technologies, including strain and strain rate. Right ventricular response and right and left ventricular interactions in experimental models of right ventricular pressure and volume loading.
Appointment Status
Fellows, Graduates, Summer Students

Research Synopsis

Detailed Description: Our lab investigates the physiologic and molecular responses, in particular myocardial fibrosis in the right and left ventricles in response to right ventricular pressure loading and pulmonary hypertension.

Keywords: myocardial fibrosis, ventricular interactions, pressure loading, pulmonary hypertension, echocardiography

Collaborators: Drs. Kim Connelly, Wolfgang Kuebler, Jason Maynes, Scott Heximer, Andras Kapus


Animal models for right ventricular pressure loading and pulmonary hypertension. Cell cultures, molecular signaling pathways, western blotting


Rodent echocardiography, conductance catheter, pressure volume tube of hemodynamics, flexcell stretch culture apparatus, hypoxia chambers


Recent Publications


Collaborator. Lumens J, Fan Cs, Walmsley J, Yim D, Manlhiot C, Dragulescu A, Grosse-Wortmann L, Mertens L, Prinzen FW, Delhaas T, Friedberg MK. Relative impact of right ventricular electro-mechanical dyssynchrony versus pulmonary regurgitation on right ventricular dysfunction and exercise intolerance in patients after repair of tetralogy of Fallot. Journal of the American Heart Association. Journal of the American Heart Association. 2019 Jan; 8(2):e010903

Senior Responsible Author. Yim D, Hui W, Larios G, Dragulescu A, Grosse-Wortmann L, Bijnens B, Mertens L, Friedberg MK. Quantification of Right Ventricular Electromechanical Dyssynchrony in Relation to Right Ventricular Function and Clinical Outcomes in Children with Repaired Tetralogy of Fallot. Journal of the American Society of Echocardiography. 2018 July; 31(7): 822-830.

Co-Author. Traister A, Patel R, Huang A, Patel S, Plakhotnik J, Lee J, Gonzalez Medina M, Welsh C, Ruparel P, Friedberg MK, Maynes J, Coles, J. Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. PLoS One. 2018 July; 13(7): e0200342. doi: 10.1371/journal.pone.0200342.

Senior Responsible Author. Son JS, James A, Fan S, Mertens L, McCrindle B, Manlhiot C, Friedberg MK. Prognostic value of serial echocardiography in hypoplastic left heart syndrome. Circulation: Cardiovascular Imaging. 2018 July; 11(7) e006983. doi: 10.1161/CIRCIMAGING.117.006983

Principle Author. Friedberg MK. Imaging Right-Left Ventricular Interactions. Journal of American College of Cardiology: Cardiovascular Imaging. 2018 May; 11(5):755-771. doi: 10.1016/j.jcmg.2018.01.028. Review



Cross-Appointed to Physiology
Primary Department: Pediatrics
Staff Cardiologist, Labatt Family Heart Centre, Division of Cardiology, Hospital for Sick Children
Senior Associate Scientist, SickKids Research Institute
Professor, Department of Pediatrics