Haibo Zhang

Cardiovascular and Respitory Platform


St. Michael's Hospital, Room 619, LKSKI 209 Victoria Street , Toronto, Ontario Canada M5B 1T8
Research Interests
Infection, immunity, lung injury, defensin biology, phagocytosis, sepsis, cytokine, toll-like receptors.

Degrees: Ph.D. 1995, M.D. 1988

Affiliations: St. Michael's Hospital

Research Synopsis

Detailed Description:

My major research interests relate to lung infection and immunity and sepsis. Specifically, my lab is working on:

  1. Human neutrophil peptides in host defense and lung injury: To examine the molecular mechanisms by which human neutrophil peptides impair phagocytic function and inflammatory responses in human cystic fibrosis and other lung diseases, and develop therapeutic approaches targeting the mechanisms of action of human neutrophil peptides.
  2. Novel LPS receptor: To identify alternative LPS receptors in lung cells and alveolar macrophages independent of TLR4.
  3. Cytokine and bacterial interaction: To examine the mechanisms by which cytokines kill and promote bacterial proliferation. My laboratory uses a number of model systems including in vitro primary human and murine cells and transformed human and murine cell lines, ex vivo lung explants and various animal models.
  4. I have been involved in clinical trials related to biomarkers of inflammation.


Cell and tissue culture: Endothelial cells.

Procedures: Elisa, gene expression analysis, immunohistochemistry, isolated vessel preparation, mass spectrometry, microarrays, proteomics, qRT-PCR, RT-PCR, signal transduction characterization, siRNA, vagotomy, western blot.


Benchtop centrifuge, blotting apparatus, confocal microscope, culture hood, culture incubators, fluorescence microscope, gel apparatus, infusion apparatus, low- and high-speed centrifuge, low and ultralow freezers, mass spectrometer, micropipette puller, microwave oven, mini vortexer, plate reader, real-time/thermocycler, setups for electropherosis, stirrer/hot plate.


Alice Luo        PhD candidate
Diana Islam        PhD candidate
Ustina Huh        MSc candidate
Florence Morriello        MSc candidate
Alice Grassi        Post Doctoral Fellow
Manshu Li          PhD exchange student
Junbo Zheng        PhD exchange student


Within the Department of Physiology:

John Laffey
Mingyao Liu
Wolfgang Kuebler
Heyu Ni
Greg Hare
David Mazer
Qinghua Wang

Outside the Department of Physiology:

Arthur Slutsky                        Critical Care Medicine/UofT
Jane Batt                     Respiratory Medicine/UotT             
Warren Lee                 Critical Care Medicine/UofT
John Marshall             Critical Care Medicine/UofT
Ian Tannock                Oncology/UofT
Gordon Winocur         Baycrest Institute Toronto
Janette Vardy              Sydney Cancer Centre/University of Sydney
Rolf Hubmayr             Respiratory Medicine/Mayo Clinic
Nanshn Zhong            Respiratory Medicine/Guangzhou Medical University

Committee member/officer of national/international scientific organizations

Reappointment committee, SMH
Appointment committee, IMS
Associate Editor, Intensive Care Medicine

Agency: CIHR
Committee: Doctoral Scholarship committee

Recent Publications


Primary: Anesthesia