PSL446H1S - Fundamentals of Neuroscience: The Molecular and Cellular Aspects of Neural Disorders

Tuesdays - 5:00 p.m. - 8:00 p.m. (In- Person)

Course Director:

Dr. Chirag M. Vaswani, PhD

Are you fascinated by the intricate workings of the brain and eager to explore the mechanisms behind neural disorders?

Do you want to engage in hands-on problem-solving with leading experts in the field?

Join us in PSL446H for an in-depth journey into the cellular and molecular aspects of neural disorders!

Course Overview:

PSL446H is an advanced course designed for both graduate and fourth-year undergraduate students interested in neurophysiology. This course provides a comprehensive understanding of the cellular and molecular mechanisms underlying various neural disorders. We cover three main themes throughout the semester, each offering unique insights and challenges.

Please note that specific topics may be subject to change year-to-year to accommodate the rapid advancements in the field.

Theme 1: Neurodegenerative and Neuroinflammatory Disorders

In this theme, we explore disorders that involve the progressive degeneration of neurons and the role of the immune system in neural damage. Topics can include Alzheimer’s disease, Parkinson’s disease, prion diseases, multiple sclerosis, and epilepsy. Key questions we will address include: What are the common pathological features of neurodegenerative diseases? How does the immune system contribute to neural damage in diseases like multiple sclerosis? What are the current therapeutic strategies for managing epilepsy, and how do they target cellular mechanisms?

Theme 2: Genetic and Developmental Disorders

The second theme focuses on conditions arising from genetic mutations or developmental abnormalities that affect brain function. We will delve into genetic models for neurodevelopment and neurodegenerative diseases, the molecular mechanisms of brain diseases, and genome-wide genetic screens to identify therapeutic targets for brain disorders. Students will explore how genetic mutations lead to developmental disorders, the impact of genetic disorders on brain function, and the unique challenges in identifying therapeutic targets.

Theme 3: Neural Injury and Repair

The final theme examines the mechanisms and consequences of neural injuries, such as spinal cord trauma, brain injury, and cerebral metabolism in critically ill patients. We will also cover brain networks and connectomics, neuromodulation, Alzheimer’s disease, stroke, and traumatic brain injury. Discussions will focus on the primary mechanisms of neural damage, changes in brain networks following injury, and key considerations in developing neuromodulation therapies.

Course Structure and Learning Approach

Each topic will be covered in a dedicated session featuring lectures from leading experts in the field, followed by group discussions and interactive case study activities. Our unique course offering- “Advanced Case Study CoffeeChats” (ACSCC)- provides a collaborative environment where students tackle real-world problems and engage in dynamic discussions.

Course Goals

Our goals for this course are to provide students with a deep understanding of the cellular and molecular mechanisms behind neural disorders, develop critical thinking and problem-solving skills through case studies and interactive discussions, and engage with leading experts to foster an interactive learning environment.

Course Restrictions

This is an AE indicator course and may be added during your enrolment start date using ROSI/ACORN but will appear with an interim status (INT) until reviewed by the department. Enrollment will be capped. Materials (slides and recommended readings, at the lecturer’s discretion) will also be posted online, in advance of each lecture. Lectures will not be recorded.

Prerequisite: PSL300H1, PSL301H1, CJH332H1 or permission of instructor A minimum grade of 78% is required in PSL300H1, PSL301H1 and CJH332H1. If minimum grade has not been met students are advised to contact the Department of Physiology at physiology.undergrad@utoronto.ca for approval.
Exclusion: PSL444Y1
Breadth Requirements: Living Things and Their Environment (4)

Exclusions: PSL444Y1Y

Evaluation: There will be two midterm tests, a term final, and collaborative in-class activities to encourage active learning. The end-of-term final will be administered through Arts & Sciences during the official exam periods. Students must complete at least one midterm to be eligible to write the final examination.

Texts: (Texts are optional)

Principles of Neuroscience, 4th edition, E.R. Kandel, V.H. Schwartz, T.M. Jessell, 2000.

Elements of Molecular Neurobiology, 2nd Edition, by C.U.M. Smith, John Wily and sons, 1996.

Join Us:

Whether you are looking to expand your knowledge in neurophysiology or aiming to contribute to the field of neuroscience, PSL446H offers an engaging and comprehensive platform to achieve your goals. Join us for an exciting and intellectually stimulating semester! We would be happy to have you!