PSL445H1F - Neuroscience - Cellular & Molecular

Course Coordinator:
Dr. Jesse Gillis, PhD

Associate Professor, Department of Physiology
University of Toronto
user: jesse.gillis  |  domain: utoronto.ca

Overview
The purpose of this course is to give graduate students an overview and grounding in the fundamentals of neuroscience.  This course designation is for the first half of a year-long lecture series whose main emphasis is on the cellular and molecular aspects of brain function.  Students may also take the second half of the course under the PSL446H designation if they would like to continue.  The lecturers, all experts in their respective topics, are drawn from the different university departments and associated research institutes. Each year the course is updated to reflect the rapid evolution of ideas in neuroscience.  The course is administered through the Department of Physiology. This course is open to both graduate and senior undergraduate students. To facilitate extensive student-instructor interaction, enrollment will be capped.

Evaluation:
There will be a total of two midterm tests (30% each) and there will be one final exam (40%).  Tests and final exam are non-cumulative, covering material only since the previous test.  Tests will be conducted during class hours.  In addition, class time will be set aside for each graduate student to present an oral critique of a relevant paper.

Optional Texts:
Principles of Neuroscience, 4th edition, E.R. Kandel, V.H. Schwartz, T.M. Jessell, 2000.
Elements of Molecular Nuerobiology, 2nd edition, C.U.M. Smith.  John Wily and Sons, 1996

Semester Schedule (topics/order subject to change):

September 3, 2024

Experimental design for molecular and cellular neuroscience

Dr. J. Gillis

September 10, 2024

Single Cell RNA-seq features of Neuronal Identity

Dr. J. Gillis

September 17, 2024

Patch-seq and multimodal single-cell methods

Dr. S. Tripathy

September 24, 2024

TERM TEST 1 (30% of overall grade)

 

October 1, 2024

Stress and the brain

Dr. J. Bains

October 8, 2024

Molecular Mechanisms of Neurotransmitter Release

Dr. S. Sugita

October 15, 2024

Signalling Pathways Regulating Neurodevelopment

Dr. K. Singh

October 22, 2024

TERM TEST 2 (30% of overall grade)

 

November 5, 2024

Molecular Regulation of Neuritic Growth, Remodeling and Regeneration

Dr. P. Monnier

November 12, 2024

Introduction and Developmental Neurobiology; Class Discussion Groups: Mechanisms – Part 1

Dr. L. Mills

November 19, 2024

Intracellular Calcium and Neuronal Development; Group Presentations: Mechanisms – Part 2

Dr. L. Mills

November 26, 2024

Electrophysiology of Central Mammalian Neurons

Dr. P. Carlen

Final Exam Period (date TBD)

FINAL EXAM (40% of overall grade)

 

No lecture is scheduled for December 3.  In the event of an earlier unavoidable lecture cancellation, this day is reserved for a potential makeup or any remaining in-class presentations.