Breadcrumbs
PSL445H1F - Neuroscience - Cellular & Molecular
Course Coordinator:
Dr. Jesse Gillis, PhD
Associate Professor, Department of Physiology
University of Toronto
user: jesse.gillis | domain: utoronto.ca
Overview
The purpose of this course is to give graduate students an overview and grounding in the fundamentals of neuroscience. This course designation is for the first half of a year-long lecture series whose main emphasis is on the cellular and molecular aspects of brain function. Students may also take the second half of the course under the PSL446H designation if they would like to continue. The lecturers, all experts in their respective topics, are drawn from the different university departments and associated research institutes. Each year the course is updated to reflect the rapid evolution of ideas in neuroscience. The course is administered through the Department of Physiology. This course is open to both graduate and senior undergraduate students. To facilitate extensive student-instructor interaction, enrollment will be capped.
Evaluation:
There will be a total of two midterm tests (30% each) and there will be one final exam (40%). Tests and final exam are non-cumulative, covering material only since the previous test. Tests will be conducted during class hours. In addition, class time will be set aside for each graduate student to present an oral critique of a relevant paper.
Optional Texts:
Principles of Neuroscience, 4th edition, E.R. Kandel, V.H. Schwartz, T.M. Jessell, 2000.
Elements of Molecular Nuerobiology, 2nd edition, C.U.M. Smith. John Wily and Sons, 1996
Semester Schedule (topics/order subject to change):
September 3, 2024 Experimental design for molecular and cellular neuroscience |
Dr. J. Gillis |
September 10, 2024 Single Cell RNA-seq features of Neuronal Identity |
Dr. J. Gillis |
September 17, 2024 Patch-seq and multimodal single-cell methods |
Dr. S. Tripathy |
September 24, 2024 TERM TEST 1 (30% of overall grade) |
|
October 1, 2024 Stress and the brain |
Dr. J. Bains |
October 8, 2024 Molecular Mechanisms of Neurotransmitter Release |
Dr. S. Sugita |
October 15, 2024 Signalling Pathways Regulating Neurodevelopment |
Dr. K. Singh |
October 22, 2024 TERM TEST 2 (30% of overall grade) |
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November 5, 2024 Molecular Regulation of Neuritic Growth, Remodeling and Regeneration |
Dr. P. Monnier |
November 12, 2024 Introduction and Developmental Neurobiology; Class Discussion Groups: Mechanisms – Part 1 |
Dr. L. Mills |
November 19, 2024 Intracellular Calcium and Neuronal Development; Group Presentations: Mechanisms – Part 2 |
Dr. L. Mills |
November 26, 2024 Electrophysiology of Central Mammalian Neurons |
Dr. P. Carlen |
Final Exam Period (date TBD) FINAL EXAM (40% of overall grade) |
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No lecture is scheduled for December 3. In the event of an earlier unavoidable lecture cancellation, this day is reserved for a potential makeup or any remaining in-class presentations.