After reviewing the anatomy and development of the heart, the ion channels and contractile proteins involved in cardiac and smooth muscle contraction will be studied. Emphasis will be placed on regulation of electrical and contractile function by kinases, metabolism, sarcomere length (volume) and ions along with alterations in function associated with cardiovascular diseases.
Prerequisites:
PSL(300H, 301H)/302Y1Y; PSL 452H1F is recommended.
Evaluation:
20%. Midterm examination.
20% Term paper (due end of class)
40% final oral debate presentation (10% of the mark from a presubmission of the debate notes; with 30% mark from the actual debate performance). Topics to be sorted out for Feb break will plenty of time to set up teams, debate points etc.
20% Final examination
