PSL1425H - Integrative Metabolism and Its Endocrine Regulation

Course Coordinators:

 A Giacca, T Lam


Goal:  This course will provide the student with current perspectives on metabolism and its endocrine regulation and emphasize the potential of the endocrine and metabolic field of investigation in obesity and diabetes research. The goal is to integrate the newest findings and experimental approaches from cellular and molecular areas into metabolic function at the tissue, organ and whole body level.

Objectives:  Upon completion of the course the student will be able:

  • To integrate the fundamentals of fuel and energy metabolism and its endocrine regulation into a whole body perspective
  • To grasp the current concepts in obesity and diabetes research
  • To start formulating hypotheses to address specific questions in the area of metabolism

Topics Covered:  Overview of carbohydrate and lipid metabolism; lipoprotein metabolism; protein metabolism; control of food intake and obesity; hormone receptors and signalling pathways; insulin action and mechanisms of insulin resistance; mechanisms of insulin secretion; type 1 and type 2 diabetes; complications of diabetes; insulin resistance, diabetes and cardiovascular disease.

Specifically for graduate students: in vitro and in vivo research techniques, animal models of obesity and diabetes (lecture format), brain regulation of metabolism, student presentations about their research areas with questions and answers.


None.  The course is intended to provide updated comprehensive knowledge in Metabolism and Diabetes.  This is expected to be especially useful to graduate students from different backgrounds. 


Common Component with Undergraduates:
10% questions in class
10% paper critique
15% midterm test
25% final assessment
Graduate Only Component:
15% class presentation
5% questions in class (Graduate lecture component)
20% literature review paper (to be handed in after the final test)

Research group affiliation: 

Endocrinology and Diabetes