Alumni Spotlight: Professor Jamie Joseph

Professor Jamie Joseph, an alumnus of Professor Michael Wheeler's lab, studies a protein called prolyl hydroxylase domain (PHD) to try to understand how beta cell dysfunction occurs.

“'Insulin is released by the pancreas, but in order for the pancreas to know when to release insulin, it has to detect how much glucose is currently in your bloodstream.'" Joseph explained in an article about his work from 2018.

“'Beta cells facilitate this process – when they’re working properly, these cells detect glucose in the bloodstream and tell the pancreas to release insulin....In people with type 2 diabetes, beta cells often stop working properly...We’re examining why and how these beta cells become defective.'”

He continues to make strides in this work and recently published a review paper in the journal Islets.

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