JCV3062H - Advanced Topics in Cardiovascular Sciences: Heart Function (Not offered 2015-16)

Course Coordinator

C. Wittnich


This course is one of a set of four advanced seminar half-credit courses dealing with current areas in the cardiovascular system. Specifically, JCV3062H covers all aspects of heart function from ultrastructure and gene regulation to whole organ and response to various environmental and disease states.

Areas that may be covered include:

  • Myocardial stress protein 

  • Endoplasmic reticulum: ultrastructure and protein composition of Ca++ storage/release sites in cardiac muscle 

  • Sarcoplasmic reticulum, calcium and its regulation in cardiac function 

  • Phospholamban in the regulation of cardiac kinetics 

  • Genetic regulation of cardiac function: cardiac myosin heavy chain genes and familial hypertrophic cardiomyopathies 

  • Genes associated with cardiovascular systems and multifactorial disease 

  • Integrative approach to the regulation of cardiac function 

  • Effect of nitric oxide on cardiac function 

  • Cardiac and vascular response to exercise 

  • Cardiac function in adverse environments 

  • Aging and the cardiovascular response

For the complete course outline, visit http://www.cscp.utoronto.ca




Grading will be based on a manuscript critique (20%), oral presentation (30%), written essay (40%) and participation (10%).


Enrolment restrictions: Graduate students or research fellows interested in heart research. Preference will be given to students enrolled in the Cardiovascular Sciences Collaborative Program.