This course is one of a set of four advanced seminar half-credit courses dealing with current areas in the cardiovascular system. Specifically, JCV3062H covers all aspects of heart function from ultrastructure and gene regulation to whole organ and response to various environmental and disease states.
Areas that may be covered include:
Myocardial stress protein
Endoplasmic reticulum: ultrastructure and protein composition of Ca++ storage/release sites in cardiac muscle
Sarcoplasmic reticulum, calcium and its regulation in cardiac function
Phospholamban in the regulation of cardiac kinetics
Genetic regulation of cardiac function: cardiac myosin heavy chain genes and familial hypertrophic cardiomyopathies
Genes associated with cardiovascular systems and multifactorial disease
Integrative approach to the regulation of cardiac function
Effect of nitric oxide on cardiac function
Cardiac and vascular response to exercise
Cardiac function in adverse environments
Aging and the cardiovascular response
For the complete course outline, visit http://www.cscp.utoronto.ca
Prerequisite:
None.
Evaluation:
Grading will be based on a manuscript critique (20%), oral presentation (30%), written essay (40%) and participation (10%).
Remarks:
Enrolment restrictions: Graduate students or research fellows interested in heart research. Preference will be given to students enrolled in the Cardiovascular Sciences Collaborative Program.
