Assistant Professor  |  Cardiovascular and Respiratory Platform

Ewan Goligher


Critical Care Program, TGH, 585 University Ave, 9-MaRS-9024, Toronto, Ontario Canada M5G 2N2
Research Interests
Respiratory muscle action and function during mechanical ventilation; mechanisms of lung and diaphragm injury in respiratory failure; management of acute respiratory failure, mechanical ventilation, and extracorporeal life support
Fellows, Graduates, Summer Students


Cross-Appointed to Physiology
Primary: Medicine
Scientist, Toronto General Hospital Research Institute
Assistant Professor
Interdepartmental Division of Critical Care Medicine, University of Toronto

Research Synopsis:

Research Interests: respiratory muscle action and function during mechanical ventilation for acute respiratory failure; respiratory mechanics in acute respiratory failure; clinical trials of mechanical ventilation strategies to improve outcomes in respiratory failure; phrenic nerve stimulation.

Keywords: respiratory failure, mechanical ventilation, respiratory muscles, respiratory mechanics, clinical trials, phrenic nerve stimulation, esophageal manometry

Detailed Description:
I study the control of respiratory drive and effort under mechanical ventilation and techniques to modulate respiratory drive and effort in order to optimize patient spontaneous breathing during mechanical ventilation and to prevent injury to the lung and diaphragm.

Collaborators: Drs. Niall Ferguson, Richard Horner


Procedures: ultrasound, esophageal manometry, esophageal EMG, electrical impedance tomography, phrenic nerve stimulation, randomized trials


Philips ultrasound, MbMed FluxMed respiratory signal acquisition system, various mechanical ventilators, electrical impedance tomography devices


Idunn Morris (MSc. Candidate)

Recent Publications

  1. REMAP-CAP Investigators., ACTIV-4a Investigators., ATTACC Investigators., Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Zarychanski R. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789.


  1. Goligher EC, Costa ELV, Yarnell CJ, Brochard LJ, Stewart TE, Tomlinson G, Brower RG, Slutsky AS, Amato MPB. Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance. Am J Respir Crit Care Med. 2021 Jun 1;203(11):1378-1385.
  2. Goligher EC, Dres M, Patel BK, Sahetya SK, Beitler JR, Telias I, Yoshida T, Vaporidi K, Grieco DL, Schepens T, Grasselli G, Spadaro S, Dianti J, Amato M, Bellani G, Demoule A, Fan E, Ferguson ND, Georgopoulos D, Guérin C, Khemani RG, Laghi F, Mercat A, Mojoli F, Ottenheijm CAC, Jaber S, Heunks L, Mancebo J, Mauri T, Pesenti A, Brochard L. Lung- and Diaphragm-Protective Ventilation. Am J Respir Crit Care Med. 2020 Oct 1;202(7):950-961.