Dec 1, 2022  |  4:00pm - 5:00pm
Physiology Seminar Series

Dr. Giancarlo Vanini: "Zooming into preoptic glutamatergic mechanisms controlling arousal, anesthesia and cortical dynamics"

~ Eligible for PSL1000H/PSL2000H/PSL4000Y Course Seminar Attendance ~    

Speaker: Giancarlo Vanini, MD

Assistant Professor, Department of Anesthesiology
Center for Consciousness Science
Michigan Neuroscience Institute Affiliate
University of Michigan Medical School

The Vanini Lab uses a systems neuroscience approach to understand how brain circuits regulate interacting states of sleep, wakefulness, anesthesia and pain. Specifically, we investigate (1) how sleep disruption can worsen ongoing pain and lead to the development of chronic pain, (2) the mechanisms underlying the loss of consciousness during states of sleep, sedation and general anesthesia, and (3) the neural basis of sleep-dependent cognitive dysfunction after a surgical insult. To this end, we use a combination of behavioral assays, electroencephalographic/electromyographic (EEG/EMG) recordings, neurochemical monitoring, calcium imaging in freely behaving mice, neuroanatomical viral tracing, as well as chemogenetic/optogenetic tools to identify and probe neural networks controlling sleep, wakefulness and nociception.

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