Department of Physiology

PSL1441H - Systems Level Neuroplasticity

Course Coordinator:  W.D. Hutchison

Changing the strength of connections between neurons has been widely assumed to be the basic mechanism by which many kinds of information are encoded and stored in the central nervous system. This course will examine the basic structure of selected sensory and motor systems and examine the nature of activity-dependent synaptic plasticity in each of these systems. We will examine auditory, vestibular, motor, limbic and memory systems in humans and animal models and then outline in each system how synaptic plasticity can modulate function at early and/or late stages of the lifespan. In contrast to this “good” plasticity, we will also examine the possibility that “bad” or aberrant synaptic plasticity underlies neurological disease processes. 

Lectures will be complemented by an essay on some aspect of adaptive brain change in one of these systems to be completed by the student.

Midterm worth 25%. Grade to be returned prior to the drop date. 
Essay worth 25%. 
Final Exam worth 50 % 


Other Teaching Faculty:
K Gordon
M.P. McAndrews
L Zhang
T. Valiente
M. Quraan

Updated: 02-Nov-2016