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Xiao-Yan WenPhD
Assistant Professor
Cardiovascular and Respiratory Platform

Contact Info

T. (416) 847-1737

Location

209 Victoria Street, LKSK, Room 519
Toronto
ON, M5B 1T8

Research Interests

1. Genome wide gene trapping and mutagenesis in zebrafish 2. Large scale high throughput chemical genetic screening for in vivo drug discovery using zebrafish embryos 3. Functional genomics and disease modeling

Accepting

Graduates

Appointments

Primary: Department of Medicine

Research/Teaching

Research Synopsis:

Research Interests:

1. Genome wide gene trapping and mutagenesis in zebrafish
2. Large scale high throughput chemical genetic screening for in vivo drug discovery using zebrafish embryos
3. Functional genomics and disease modeling

Keywords: Zebrafish, disease modeling, high throughput, mutagenesis, gene trapping, chemical genetics, drug development.

METHODS USED

Cell and tissue culture: Brain slice, cardiomyocytes, endothelial cells, pancreas cells.

Procedures: Behavioural tests, gene expression analysis, immunohistochemistry, qRT-PCR, RT-PCR, western blot.

EQUIPMENT USED

Amplifier, analytical balances, benchtop centrifuge, blotting apparatus, confocal microscope, culture hood, culture incubators, digital microscope, dissecting microscope, electrometer, fluorescence microscope, microwave oven, plate reader.

PRESENT TRAINEES

Jennifer Tat
Wing Hui
David Spillane
Suzan El-Rass
Antonio Mauro
Filip Miscevic

Publications and Awards

Recent Publications

http://www.ncbi.nlm.nih.gov/pubmed/26020268

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