chauhan
Vijay S. ChauhanPhD
Associate Professor
Cardiovascular and Respiratory Platform

Contact Info

T. (416) 340-3172
F. (416) 340-4710

Location

PMCC 3-522, Toronto General Hospital, 150 Gerrard St. W.
Toronto
ON, M5G 2C4

Research Interests

Heart, repolarization, cardiomyopathy, imaging, sudden death, body surface and intracardiac recordings

Accepting

None

Degree/Qualifications

MD, F.R.C.P(C)

Appointments

Primary: Medicine.

Research/Teaching

Research Synopsis:

Detailed Description:
Dr. Chauhan has established a productive translational electrophysiology research program supported by the Heart and Stroke Foundation of Ontario and the Canadian Foundation for Innovation. The program is characterizing cardiac repolarization dynamics in patients with cardiomyopathy as it related to the pathogenesis of lethal ventricular tachyarrhythmias. Although experimental studies suggest that abnormal ventricular repolarization is responsible for ventricular arrhythmias and sudden death, the relevance of cardiac repolarization as a substrate for arrhythmogenesis in humans is less clear. His laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from these studies will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in patients with heart disease which may lead to the development of novel antiarrhythmic therapies.

METHODS USED

Procedures Electrophysiology, in-vivo electrophysiology.

EQUIPMENT USED

Amplifier, electrophysiology rig, stimulator.

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