jin
Tianru JinPhD
Professor
Endocrine and Diabetes Platform

Contact Info

T. (416) 581-7670
F. (416) 581-7880

Location

10-354, MaRS Building 101 College St. Toronto
Toronto
ON, M5G 1L7

Research Interests

1) Understanding cell type specific gene transcription. 2) Mechanisms underlying the production and function and the incretin hormone GLP-1. 3) Role of Wnt signaling pathway in metabolic homeostasis.

Accepting

None

Appointments

Primary: Medicine

Research/Teaching

Research Synopsis:

Research Divisions: Endocrine and Diabetes Platform

Research Interests:
1) Understanding cell type specific gene transcription.
2) Mechanisms underlying the production and function and the incretin hormone GLP-1.
3) Role of Wnt signaling pathway in metabolic homeostasis.

 

Keywords: Wnt, cAMP, PKA, diabetes, glucagon, GLP-1, TCF7L2, Transgenic mice, Epac, beta-catenin, Insulin Insulin resistance, Molecular biology, Oxidative stress, Proglucagon-derived peptides, Transcription

Detailed Description:
This research lab is supported by CIHR, CDA and BBDC in examining role of signaling molecules (including Wnt molecules, insulin, and cAMP) and transcription factors in regulating the expression of the proglucagongene (gcg), and the synthesis and secretion of gcg-encoded peptide hormones.. The lab is also interested in exploring the role of Wnt signaling pathway in mediating the function of the incretin hormone GLP-1, and the overall role of Wnt signaling in metabolic homeostasis.

METHODS USED

Cell and tissue culture: Pancreas cells.

Procedures: Adenovirus, gene expression analysis, mass spectrometry, microarrays, proteomics, qRT-PCR, RIA, RT-PCR, signal transduction characterization, siRNA, western blot.

EQUIPMENT USED

benchtop centrifuge, culture hood, culture incubators, gel apparatus, microwave oven.

PRESENT TRAINEES

Alex Chiang, Ph.D.
Wilfred Ip, Ph.D.

PRESENT COLLABORATIONS

Within the Department of Physiology
Herbert Gaisano
Michael Wheeler
Qinghua Wang

Outside of the Department of Physiology
Jonathan Chernor, Fox Chase Cancer Centre/ USA
Weihua Ling, Sun Yat-University/P. R. China

Committee member/officer of national/international scientific organizations
Editorial Board Member: Am. J. Physiology (Endocrinology/Metabolism)
Academic Editor: Plos One.
Editor: Frontiers in Endocrinology

Publications and Awards

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