Harrison
Robert V. HarrisonPhD
Professor
Neuroscience Platform

Contact Info

T. (416) 813-6535
F. (416) 813-7717

Location

The Hospital for Sick Children, Department of Otolaryngology Head and Neck Surgery, 555 University Avenue
Toronto
ON, M5G 1X8

Research Interests

Physiology, morphology and developmental plasticity of the normal and pathological auditory system. Hearing disorders, Cochlear implantation.

Accepting

None

Appointments

Primary: Otolaryngology - HNS

Research/Teaching

Research Synopsis:

Research Interests: Auditory system anatomy and physiology; cochlear mechanisms; developmental plasticity of the auditory system; hearing disorders; auditory neuroscience; coding of sound in the auditory brainstem, midbrain and cortex; cochlear implantation; early diagnosis of hearing disorders; epidemiology of hearing loss; noise induced hearing loss; auditory neuropathy; otoacoustic emissions; auditory brain imaging.

Keywords: hearing; deafness; auditory system; cochlear implantation; auditory neuropathy; developmental plasticity; brain development; electrophysiology; otoacoustic emissions; auditory brainstem evoked responses; auditory psychophysics; c-fos; electron microscopy, microelectrode (single unit) electrophysiology; corrosion casting; vasculature of the cochlea.

METHODS USED

Procedures:  EEG, electrophysiology, evoked potential recording, immunohistochemistry, in-vivo electrophysiology, otoacoustic emission recording.

EQUIPMENT USED

Amplifier, Fluorescence Microscope, Micropipette puller, Motoized micromanipulators.

PRESENT TRAINEES

Lisa D'Allesandro (Physiology)
Mattia Carraro (IBBME)

PRESENT COLLABORATIONS

Lu-Yang Wang

Outside the Department of Physiology:

Vincent Lin                      Otolaryngology -HNS, Sunnybrook RI
Karen Gordon                 Otolaryngology -HNS, SickKids RI
Evan Propst                   Otolaryngology -HNS, SickKids
Adrian  James                  Otolaryngology -HNS, SickKids
Blake Papsin                 Otolaryngology -HNS, SickKids
Paolo Campisi              Otolaryngology -HNS, SickKids

Committee member/Officer of national or international scientific organization:

Council of Canadian Academies, expert panel on Wind Turbine Noise and Human health
Elected member, International Academy of Otorhinolaryngology – HNS
Vice Chair - research, Department of Otolaryngology – HNS, University Toronto
Elected member: Collegium Oto-Rhino-Laryngologicum Amiticitiae Sacrum (CORLAS)
Scientific Advisory Committee, Ontario Health Study (OHS)

Publications and Awards

Recent Publications

HARRISON RV. (2008) Noise-induced hearing loss in children: a ‘less than silent’ environmental danger. Paediatr Child Health 2008; 13 (5): 377-382.

DAVIDS T, VALERO J, PAPSIN BC, HARRISON RV, GORDON KA (2008) Effect of increasing duration of stimulation on the electrically evoked auditory brainstem and middle latency responses in pediatric cochlear implant users.  Journal of Otolaryngology-Head & Neck Surgery. 2008  37: 559-564.

CHUGH BP,  LERCH JP, YU  LX, PIENKOWSKI  M, HARRISON  RV, HENKELMAN  RM  SLED JG. (2009)  Measurement of Cerebral Blood Volume in Mouse Brain Regions using Micro-Computed Tomography.  NeuroImage 47 (2009) 1312–1318

BROWN TA, HARRISON RV. (2009) Responses of neurons in chinchilla auditory cortex to frequency modulated tones. J Neurophysiol 101: 2017-2009.

BROWN TA, HARRISON RV. (2010) Postnatal development of neuronal responses to frequency-modulated tones in chinchilla auditory cortex. Brain Res. 14;1309:29-39.

HOLLER T, ALLEGRO J, CHADHA NK, HAWKES M, HARRISON RV, FORTE V, CAMPISI P.(2009) Voice outcomes following repeated surgical resection of laryngeal papillomata in children. Otolaryngol Head Neck Surg.141(4):522-6.

ALLEGRO J, PAPSIN BC, HARRISON RV, CAMPISI P (2010) Acoustic Analysis of Voice in Pediatric Cochlear Implant Recipients with Post-Meningitic Hearing Loss. Coch Impl Internat.11(2) 100-116.

SCHRAMM DR, HARRISON RV. (2010) Performance after Cochlear Implantation in Children with Auditory Neuropathy  Coch. Impl. Int. 11 207-212.

BROWN TA, HARRISON RV. (2011) Neuronal responses in chinchilla auditory cortex after postnatal exposure to frequency-modulated tones. Hear Res. 275 8-16

HOLLER T, CAMPISI P, ALLEGRO J, CHADHA NK, HARRISON RV, PAPSIN B, GORDON K. (2010) Abnormal voicing in children using cochlear implants. Arch Otolaryngol Head Neck Surg. 136(1):17-21

DAVIDS T, MOUNT RJ, BLASER S, , CAMPISI P HARRISON RV. (2011)  CT study of acoustic signal pathway through    the middle ear of the sperm whale (Physeter macrocephalus). Canadian Acoustics 39 (4) 13-17

ASRAR S, KANEKO K, TAKAO K, NEGANDHI J, MATSUI M, SHIBASAKI K, MIYAKAWA T, HARRISON RV, JIA Z, SALTER MW, TOMINAGA M, FUKUMI-TOMINAGA T. DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze. Mol Brain. 2011 Oct 21; 4:39, 1-11.

HARRISON RV, NEGANDHI J. (2012)  Resting neural activity patterns in auditory brainstem and midbrain in conductive hearing loss. Acta Otolaryngol. 132: 409-414.

KANDASAMY T, CLINKARD D, QIAN W, CHEN S, CHEN J, HARRISON RV, LIN VINCENT (2012) Changes in expression of VEGF and its receptors in the aging mouse cochlea – Part 1: The normal hearing mouse. J.Otolaryngol Head Neck Surg 41 Suppl 1: S36-42.

HARRISON RV.  (2012)  The prevention of noise induced hearing loss in children  Int Journal Pediatrics, 2012 Article ID 473541, pp13 doi: 10.1155/2012/473541

HARRISON RV, KONOMI U, KANOTRA S, JAMES A. (2013)  Postnatal maturation of contralateral DPOAE suppression in a precocious animal model (chinchilla) of the human neonate. Acta Otolaryngol. 2013 133:383-9.

PROPST EJ, NGAN BY, MOUNT RJ, MARTIN-MUNOZ D, BLASER S, HARRISON RV, CUSHING SL, PAPSIN BC. (2013) Ossicular fusion and cholesteatoma in auriculo-condylar syndrome: In vivo evidence of arrest of embryogenesis. Laryngoscope. 2013 123: 528-32.

HARRISON AL, NEGANDHI J, ALLEMANG C, D’ALESSANDRO L, HARRISON RV   (2013) Acoustic cross-over between ears in mouse (mus musculus): determination using a novel ABR based bio-assay. Canadian Acoustics 41: 5-10.

CLINKARD D, AMOODI H, KANDASAMY T, GREWAL AS, CHEN S, QIAN W, CHEN JM, HARRISON RV, LIN VY. Changes in the cochlear vasculature and vascular endothelial growth factor and its receptors in the aging C57 mouse cochlea.  ISRN Otolaryngol. 2013 Jun 27;2013:430625. doi: 10.1155/2013/430625.

KUS LH, NEGANDHI J, SKLAR MC, ESKANDER A, ESTRADA M, HARRISON RV, CAMPISI P, FORTE V, PROPST EJ. (2014). Angiogenesis in costal cartilage graft laryngotracheoplasty: A corrosion casting study in piglets. Laryngoscope. 2014 Jan 15. [Epub ahead of print]

CARRARO M, NEGANDHI J, KUTHUBUTHEEN J, PROPST EJ, KUS L, LIN VY, HARRISON RV. Attenuating Cardiac Pulsations within the Cochlea: Structure and Function of Tortuous Vessels Feeding Stria Vascularis. ISRN Otolaryngol. 2013 May 19;2013:941757. doi: 10.1155/2013/941757.

KUS LH, NEGANDHI J, SKLAR MH, ESKANDER A, ESTRADA M, HARRISON RV, CAMPISI P, FORTE V, PROPST EJ. Corrosion casting of the subglottis following endotracheal tube intubation injury: a pilot study in Yorkshire piglets. Journal of Otolaryngology - Head & Neck Surgery 2013, 42:52  doi:10.1186/1916-0216-42-52

WOLTER NE, HARRISON RV, JAMES AL. (2014). Separating the contributions of olivocochlear and middle ear muscle reflexes in modulation of distortion product otoacoustic emission levels. Audiol Neurootol. 2014;19(1):41-8.

PAPSIN E, HARRISON AL, CARRARO M, HARRISON RV (2014) Contralateral Ear Occlusion for Improving the Reliability of Otoacoustic Emission Screening Tests. Int J Otolaryngol. 2014;2014:248187. doi: 10.1155/2014/248187.

GRANDE G, NEGANDHI J, HARRISON RV, WANG L-W. (2014). Remodeling at the calyx of Held-MNTB synapse in mice developing with unilateral conductive hearing loss. J Physiol. 2014 Apr 1;592(Pt 7):1581-600. doi: 10.1113/jphysiol. 2013.268839.

KONOMI U, HARRISON RV, KANOTRA S, JAMES A. (2014) Age related changes to the dynamics of contralateral DPOAE suppression human subjects. J Otolaryngol Head Neck Surg. 2014 Jun 16;43:15. doi: 10.1186/1916-0216-43-15.

NEGANDHI J, HARRISON AL, ALLEMANG C, HARRISON RV. (2014) The time course of cochlear injury discharge (excitotoxicity) determined by ABR monitoring of the contralateral cochlear events. Hear Res 26;315C:34-39. doi: 10.1016/j.heares. 2014.06.002.

D’ALESSANDRO L, HARRISON RV. (2014) Excitatory and inhibitory tonotopic bands in chinchilla inferior colliculus revealed by c-fos immuno-labeling. Hear Res Oct; 316:122-8. doi: 0.1016/j.heares.2014.07.010. Epub 2014 Aug 23. PMID: 25158304  

HARRISON RV. (2014) On the biological plausibility of wind turbine syndrome. Int J Environ Health Res. 2014 Oct 8:1-6. [Epub ahead of print]  PMID: 25295915

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