jankov
Robert P. JankovPhD
Associate Professor
Reproduction and Development Platform

Contact Info

T. (416) 813-6773
F. (416) 813-5492 x416

Location

Peter Gilgan Centre for Research and Learning, 686 Bay Street, 9th Floor, Room 09.9709
Toronto
ON, M5G 0A4

Research Interests

Growth Factors; Oxidative stress; Vascular Remodeling; Vasoconstriction; Cardiac Failure

Accepting

None

Appointments

Primary: Paediatrics; Staff Physician
Division of Neonatology; Senior Scientist
Physiology and Experimental Medicine Program, Hospital for Sick Children.

Degrees: M.B., B.S, Ph.D, F.R.A.C.P

Research/Teaching

Research Synopsis:

Research Interests: Cellular and molecular mechanisms of pulmonary vascular remodelling and right heart failure in chronic pulmonary hypertension
Development and evaluation of therapies in small animal models of chronic neonatal pulmonary hypertension
Biology of nitric oxide

Detailed Description: Our lab studies the cellular and molecular mechanisms of vascular remodeling, right-ventricular dysfunction and nitric oxide unresponsiveness in pulmonary hypertension during early life. The overall goal of this research is to help develop new therapies, which might allow for improvements in quality of life and survival. Specific mechanisms under study in both the lung and heart include the roles of inflammatory cells, free radicals, NO metabolites and growth factors, using both in vitro and in vivo models. Promising therapies currently under evaluation include targeted antioxidants, Rho-kinase inhibitors, sustained hypercapnia and inhibitors of smooth muscle growth factor signaling.

METHODS USED

Cell and tissue culture: Artery cultures, smooth muscle cells, Cardiomyocytes, Endothelial cells.

Procedures: Elisa, gene expression analysis, immunohistochemistry, immunocytochemistry, microarrays, qRT-PCR, RT-PCR, siRNA, western blot.

EQUIPMENT USED

Fluorescence Microscope

PRESENT TRAINEES

Amish Jain
Matthew Wong

PRESENT COLLABORATIONS

Within the Department of Physiology:
Jaques Belik
Keith Tanswell
Brian Kavanagh
Patrick McNamara
Wolfgang Kuebler

Outside Department of Physiology:

Kim Connelly      (Medicine, University of Toronto)

Committee member/Officer of national or international scientific organization:American Physiological Society

American Physiological Society
American Thoracic Society
Canadian Paediatric Society
Nitric Oxide Society
European Respiratory Society
Perinatal Research Society
Society for Free Radical Biology and Medicine
Society for Pediatric Research

Publications and Awards

Recent Publications

Hartmut Grasemann, Rupinder Dhaliwal, Julijana Ivanovska, Crystal Kantores, Patrick J McNamara, Jaques Belik, Jeremy A. Scott and Robert P. Jankov: Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling and collagen deposition in neonatal rat lungs.  American Journal of Physiology: Lung Cellular and Molecular Biology 2015; 308:L503-L510. 

Kiranjot Gosal, Kristyn Dunlop, Rupinder Dhaliwal, Julijana Ivanovska, Crystal Kantores, Patrick J McNamara, Jean François Desjardins, Kim A Connelly, Amish Jain and Robert P Jankov: Rho-kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.  American Journal of Respiratory Cell and Molecular Biology  (October 22, 2014) doi: 10.1165/rcmb.2014-0201OC  

Kristyn Dunlop, Kiranjot Gosal, Rupinder Dhaliwal, Crystal Kantores, Julijana Ivanovska, Jean-François Desjardins, Kim A Connelly, Amish Jain, Patrick J McNamara and

Robert P Jankov: Therapeutic hypercapnia prevents inhaled nitric oxide-induced right ventricular systolic dysfunction in juvenile rats.  Free Radical Biology & Medicine 2014; 69:35-49.

Alvin H Lee, Rupinder Dhaliwal, Crystal Kantores, Julijana Ivanovska, Kiranjot Gosal, Patrick J McNamara, Michelle Letarte, Robert P Jankov: ROCK inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation.  American Journal of Respiratory Cell and Molecular Biology 2014; 50:61-73.

Back to Top