Research InterestsGrowth Factors; Oxidative stress; Vascular Remodeling; Vasoconstriction; Cardiac Failure
Degrees: M.B., B.S, Ph.D, F.R.A.C.P
Research Interests: Cellular and molecular mechanisms of pulmonary vascular remodelling and right heart failure in chronic pulmonary hypertension
Development and evaluation of therapies in small animal models of chronic neonatal pulmonary hypertension
Biology of nitric oxide
Detailed Description: Our lab studies the cellular and molecular mechanisms of vascular remodeling, right-ventricular dysfunction and nitric oxide unresponsiveness in pulmonary hypertension during early life. The overall goal of this research is to help develop new therapies, which might allow for improvements in quality of life and survival. Specific mechanisms under study in both the lung and heart include the roles of inflammatory cells, free radicals, NO metabolites and growth factors, using both in vitro and in vivo models. Promising therapies currently under evaluation include targeted antioxidants, Rho-kinase inhibitors, sustained hypercapnia and inhibitors of smooth muscle growth factor signaling.
Cell and tissue culture: Artery cultures, smooth muscle cells, Cardiomyocytes, Endothelial cells.
Procedures: Elisa, gene expression analysis, immunohistochemistry, immunocytochemistry, microarrays, qRT-PCR, RT-PCR, siRNA, western blot.
Within the Department of Physiology:
Outside Department of Physiology:
Kim Connelly (Medicine, University of Toronto)
Committee member/Officer of national or international scientific organization:American Physiological Society
American Physiological Society
American Thoracic Society
Canadian Paediatric Society
Nitric Oxide Society
European Respiratory Society
Perinatal Research Society
Society for Free Radical Biology and Medicine
Society for Pediatric Research
Publications and Awards
Hartmut Grasemann, Rupinder Dhaliwal, Julijana Ivanovska, Crystal Kantores, Patrick J McNamara, Jaques Belik, Jeremy A. Scott and Robert P. Jankov: Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling and collagen deposition in neonatal rat lungs. American Journal of Physiology: Lung Cellular and Molecular Biology 2015; 308:L503-L510.
Kiranjot Gosal, Kristyn Dunlop, Rupinder Dhaliwal, Julijana Ivanovska, Crystal Kantores, Patrick J McNamara, Jean François Desjardins, Kim A Connelly, Amish Jain and Robert P Jankov: Rho-kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology (October 22, 2014) doi: 10.1165/rcmb.2014-0201OC
Kristyn Dunlop, Kiranjot Gosal, Rupinder Dhaliwal, Crystal Kantores, Julijana Ivanovska, Jean-François Desjardins, Kim A Connelly, Amish Jain, Patrick J McNamara and
Robert P Jankov: Therapeutic hypercapnia prevents inhaled nitric oxide-induced right ventricular systolic dysfunction in juvenile rats. Free Radical Biology & Medicine 2014; 69:35-49.
Alvin H Lee, Rupinder Dhaliwal, Crystal Kantores, Julijana Ivanovska, Kiranjot Gosal, Patrick J McNamara, Michelle Letarte, Robert P Jankov: ROCK inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation. American Journal of Respiratory Cell and Molecular Biology 2014; 50:61-73.