Research InterestsCardio-pulmonary physiology; vascular reactivity; cerebral vascular disease; coronary vascular disease; hypoxia; hypercapnia; carbon monoxide kinetics; pharmacokinetics of anesthetic vapours.
Department of Anesthesiology, University Health Network
Professor, Faculty of Medicine, University of Toronto, Candada
Senior Scientist, Division of Advanced Diagnostics, Cardiovascular
Toronto General Research Institute
Chief Scientist, Thornhill Research Inc.
Brain Research and Integrated Neurophysiology
The development of novel means for precise control of blood gas partial pressures through ventilation and the applications of this technology to study
a) the vascular components of various neurological and heart diseases and the development of novel imaging methods using magnetic resonance imaging (MRI).
b) the control of the rate of uptake and elimination of various hydrocarbons and other gases through the lungs; specifically, accelerating the elimination of anesthetics and toxins such as carbon monoxide from the body
c) non-invasively determining cardiac output by following the body’s handling of a transient inhalation of a small amount of carbon dioxide
d) adaptation to the scarcity of oxygen at extreme altitude
Keywords: Cardio-pulmonary physiology; vascular reactivity; cerebral vascular disease; coronary vascular disease; hypoxia; hypercapnia; carbon monoxide kinetics; pharmacokinetics of anesthetic vapours.
Detailed Description: Our studies are on humans and large animal models. Our studies involve integrative physiology.
Procedures: Plethysmographic blood pressure; transcranial Doppler, magnetic resonance imaging, breathing circuits controlling arterial blood gases, invasive arterial blood gases, ventilatory parameters, cardiac output via thermodilution and respiratory Fick (non invasive).
Computerized gas blender; ECG, MRI, tidal gas partial pressure analyzers; arterial and venous blood gas analyzers; blood pressure transducers; thermodilution catheters and analyzers; MRI; Trans-cranial Doppler; Finger plethysmography; arterial blood gases.
Within the Department of Physiology:
Outside the Department of Physiology:
David Mikulis, Radiology/U Toronto/Canada
Rohan Dharmakumar, Cardiology/Cedars-Sinai, Los Angeles CA
Gowland Penny, MRI Physics/U Nottingham/UK
Alan Mutch, Anesthesiology/U Manitoba/Canada
Phil Ainslie, Kinesiology/U British Columbia/Canada
Kelvin Lim, Neuroscience/U Minnesota/USA
Hoge Richard, MRI Physics/U Montreal/Canada
Publications and Awards
Retinal arteriolar vascular reactivity response to hypercapnia in young normals assessed with the Canon Laser Blood Flowmeter