rocheleau
Jonathan RocheleauPhD
Associate Professor
Endocrine and Diabetes Platform

Contact Info

T. (416) 581-7839
F. (416) 581-7839

Location

10-361, Toronto Medical Discovery Tower, MaRS, Discovery District
Toronto

Research Interests

Molecular physiology of islet biology – metabolism, insulin secretion, and receptor tyrosine kinases.

Accepting

None

Appointments

Primary: Institute of Biomaterials and Biomedical Engineering
Department of Medicine, Endocrinology

Degrees: Ph.D. 2000

Affiliations: Scientist, UHN

Courses Taught : BME595, BME358, BME1460 (organizer)

Research/Teaching

Research Synopsis:

Keywords: Diabetes, pancreatic islet, two-photon microscopy, fluorescence microscopy, microfluidics.

Detailed Description: Interaction between pancreatic islets and vascular endothelial cells is necessary for the maintenance of β-cell mass and function. Aside from acting as a conduit for molecular oxygen, vascular endothelial cells in vivo secrete the majority of islet extracellular matrix (ECM). This ECM likely provides a permissive signal for β-cell proliferation, contributing to the coordinated hyperplasia of these tissues during the early stages of Type 2 diabetes. This ECM also provides a reservoir for heparin binding growth factors that further modulate this hyperplasia, including fibroblast growth factor (FGF) and vascular endothelial growth factor-A (VEGF-A). We hypothesize that communication between β-cells and vascular endothelial cells directs the proliferation and function of both tissues.

METHODS USED

Cell and tissue culture: Pancreas cells.

Procedures: Western blot.

EQUIPMENT USED

Confocal microscope, culture incubators, dissecting microscope, fluorescence microscope.

PRESENT TRAINEES                                                                                                        

Sankar,            Krishana
Silva,               Pamuditha
Ming,              Aaron
Cameron,        William
Fung,               Winnie (co-supervised)
Chen                Ian (co-supervised)

PRESENT COLLABORATIONS

Within the Department of Physiology:

Michael           Wheeler

Outside the Department of Physiology:

Warren            Chan                IBBME
Michelle         Bendeck          LMP
Penney                        Gilbert            IBBME
Scott                Gray-Owen     Molecular Genetics

PRESENT GRANT COMMITTEES SERVED ON

Agency: Canadian Diabetes Association

Committee: Islet Biology Panel

Publications and Awards

Recent Publications

http://www.ncbi.nlm.nih.gov/pubmed/26185171

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