bocking
Alan BockingMD, FRCS(C)
Professor
Reproduction and Development Platform

Contact Info

T. (416) 586-4800 Ext. 5635

Location

Mount Sinai Hospital
60 Murray Street, Room 6-1017
Toronto
ON, M5T 1X5

Research Interests

Preterm Labour, pregnancy cohorts, microbiome

Accepting

None

Professional Memberships

Fellow of the Royal College of Physicians and Surgeons of Canada, the Society of Obstetrics and Gynaecology of Canada and the American Gynecological and Obstetrical Society

Appointments

Obstetrics & Gynecology

Departments of Obstetrics and Gynaecology
Associate Scientist at the Lunenfeld-Tanenbaum Research Institute
Mount Sinai Hospital

Research/Teaching

Research Synopsis:

Research Interests: Preterm Labour

Dr. Alan Bocking is a Professor in the Departments of Obstetrics and Gynaecology and Physiology at the University of Toronto and Associate Scientist at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital. He is a Past President of the Canadian Association of Academic Professionals in Obstetrics and Gynaecology (APOG), and is a Fellow of the Royal College of Physicians and Surgeons of Canada, the Society of Obstetrics and Gynaecology of Canada and the American Gynecological and Obstetrical Society. He is the former Gordon C. Leitch Chair of the University of Toronto, Department of Obstetrics and Gynaecology and Chief of the Department of Obstetrics and Gynaecology at Mount Sinai Hospital, the University Health Network and Women’s College Hospital.

Dr. Bocking’s main areas of study are the mechanisms underlying infection–mediated preterm labour including the role of the vaginal microbiome. His other research interests include developing new diagnostic tests for preterm labour, as well as creating Research Infrastructures to study the developmental origins of health and disease. (DOHaD). He currently Chairs the Steering Committee for the Ontario Birth Study based at Mount Sinai Hospital.

Dr. Bocking has contributed significantly to the enhancement of Clinical Care, Research and Teaching in the Department of Reproductive Health at Moi University School of Medicine in Eldoret, Kenya. He was the Founding Director of the Academic Model for Provision of Access to Health Care – Reproductive Health Program,(AMPATH-RH) from 2008 – 2014.

Dr. Bocking is a member of the Board of Directors of the Maternal Infant, Child and Youth Research Network (MICYRN). He is the Vice-President of the Molly Towell Perinatal Research Foundation which funds basic and translational research in the field of Perinatal Medicine and is a member of the Advisory Board of the CIHR Institute of Human Development, Child and Youth Health.

METHODS USED

Cell and tissue culture: Human placenta and membranes.

Procedures: Immunohistochemistry, immunocytochemistry, vessel cannulation.

PRESENT TRAINEES

Grace Siwen Yang

PRESENT COLLABORATIONS

Within the Department of Physiology:
Stephen Lye

Outside of the Department of Physiology:
Oksana Shynlova, Obstetrics and Gynaecology/ Univ. of Toronto
Jonathan Maguire, Pediatrics/Univ. of Toronto
Gregor Reid, Microbiology/ Univ. of Western Ontario
Greg Gloor, Microbiology/Univ. of Western Ontario
Sung Kim, Microbiology/Univ. of Western Ontario

Publications and Awards

Recent Publications

Siwen Yang, Wei Li, John JRG Challis, Gregor Reid, Sung O Kim, and Alan D Bocking. Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice. American Journal of Obstetrics and Gynecology. 2014 Jan. In Press. Senior Responsible Author.

Parkington HC, Kenna K.R. Sozo F. Coleman H.A. Bocking A. Brien J.F. ,Harding R. Walker D.W. Tare M. Maternal alcohol consumption in pregnancy enhances arterial stiffness and alters vasodilator function that varies between vascular beds in fetal sheet. Journal of Physiology. 2014. In Press. Coauthor or Collaborator.

Wei Li, Siwen Yang, Sung O. Kim, , Gregor Reid, John R. G. Challis A.D. Bocking. Lipopolysaccharide-Induced Profiles of Cytokine, Chemokine, and Growth Factors Produced by Human Decidual Cells Are Altered by Lactobacillus rhamnosus GR-1Supernatant. Reproductive Sciences. 2014 Jan. PMID:24429676 Co-Principal Author.

I. Zelner, K. Kenna, J.Brien, A.D. Bocking, R. Harding, D. Walker, G.Koren. Meconium Fatty Acid Ethyl Esters as Biomarkers of Late Gestational Ethanol Exposure and Indicator of Ethanol-Induced Multi-Organ Injury in Fetal Sheep PLOS One 2013;8(3):e59168. doi: 10.1371. PLOS One. Coauthor or Collaborator.

McDonald SW, Lyon AW, Benzies KM, McNeil DA, Lye SJ, Dolan SM, Pennell CE, Bocking AD, Tough SC. The All Our Babies pregnancy cohort: design, methods, and participant characteristics. BMC pregnancy. 13 Suppl 1:S2. doi: 10.1186/1471-2393-13-S1-S2. Epub 2013 Jan 31. Coauthor or Collaborator.

Challis J. Newnham J. Petraglia F. Yeganegi M. Bocking A. Fetal Sex and Preterm Birth. Placenta, 2012 Dec. 19 . doi:pii: S0143-4004. Co-Principal Author.

Abstracts
 

2014 Mar - Oral administration of Lactobacillus rhamnosus GR-­1 alters the vaginal microbiome profile but not the cecal microbiome in pregnant CD-­1 mice. 61st Annual Society for Gynecologic Investigation Scientific Meeting. Florence, Italy. Presenter(s): SW Yang, W Li, O Shynlova, S Lye, JRG Challis, G Reid, GB Gloor,A.D. Bocking.

2013 Mar - Probiotic Lactobacillus rhamnosus GR-1 supernatant blocks Lipopolysaccharide (LPS)-induced preterm birth in pregnant CD-1 mice through a progesterone independent pathway. 60th Annual Society for Gynecologic Investigation Scientific Meeting. Orlando, Florida, United States. Presenter(s): Yang S.W. Li W. Challis R.G. Reid, G. Kim, S.O. Bocking, A.D.

2013 Mar - Oral administration of live Lactobacillus rhamnosus GR-1 bacteria alters the vaginal microbiome profile in Pregnant CD-1 Mice. 60th Annual Society for Gynecologic Investigation Scientific Meeting. Orlando, Florida, United States. Presenter(s): Yang S.W. Li W. Challis R.G. Reid, G. Kim, S.O. Bocking, A.D.

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